Neutrophils Set Extracellular Traps to Injure Lungs in Coronavirus Disease 2019

نویسندگان

چکیده

SARS-CoV-2 induced lower respiratory tract (LRT) disease can deteriorate to acute distress syndrome (ARDS). Because the release of neutrophil extracellular traps (NETs) is implicated in ARDS pathogenesis, we investigated presence NETs and correlates pathogenesis blood LRT samples critically ill COVID-19 patients. Plasma NET levels peaked early after ICU admission correlated with RNA load sputum neutrophil-recruiting chemokines inflammatory markers plasma. Baseline plasma quantity severity, but was not associated soluble thrombosis nor development thrombosis. High were present persisted during course COVID-19, consistent detection bronchi alveolar spaces lung tissue from fatal Thus, are produced retained critical patients could contribute SARS-CoV-2-induced pathology. .

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ژورنال

عنوان ژورنال: The Journal of Infectious Diseases

سال: 2021

ISSN: ['1537-6613', '0022-1899']

DOI: https://doi.org/10.1093/infdis/jiab053